Positive Pre-Clinical Results for Non-Alcoholic Steatohepatitis (NASH)

Afimmune obtains a granted patent covering the use of DS102 to treat fatty liver disorders
November 9, 2015
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Positive Pre-Clinical Results for Non-Alcoholic Steatohepatitis (NASH)

Afimmune today announced positive results with its anti-fibrotic compound DS102 in preclinical studies which assessed its potential effectiveness for the treatment of non-alcoholic steatohepatitis (NASH).

DS102 was tested in an In Vivo Efficacy STAM™ model, an indication specific standard for NASH, over two different time periods, all of which demonstrated a clear potential for the treatment of NASH with DS102. The STAM™ model is created by a combination of chemical and dietary interventions in C57BL/6 mice.

Treatment with DS102 statistically significantly decreased the non-alcoholic fatty liver disease activity score (NAS), a clinical endpoint for assessing the activity of NASH. Importantly, DS102 also showed a statistically significant decrease in both liver fibrosis (a critical endpoint in liver disease and marker of organ deterioration) and alanine aminotransferase (ALT), a liver injury marker. The significant anti-NASH effects were consistently reproducible.

A programme of toxicology studies carried out to date in two animal species confirms the excellent safety profile of the compound.

The results support progressing DS102 into Phase I clinical trials in 2015 with a view to its commercial launch as a safe and effective treatment for NASH, liver disease and other fibrotic indications.

About Afimmune:

Afimmune Limited (Afimmune), headquartered in Dublin, Ireland, is a drug discovery and development company working on inflammatory conditions of the human primary organs including the liver and the lung.

Afimmune: [email protected]

Updated 2016